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Esses efeitos parecem ser mediados por alteraes nos padres de expresso gnica, em vez de agonismo direto do receptor

S., Schrder, K

The vitamin B12TCN2 receptor, CD320, is downregulated in the brains of MS patients: this can then be restored by fingolimod that functionally antagonizes S1P1 and upregulates CD320, Chun and Kihara explained